Central administration of palmitoylethanolamide minimizes hyperalgesia in mice by using inhibition of NF‐κB nuclear signalling in dorsal root ganglia. Eur J PharmacolThis can be of worth with regard to your catabolism of exogenous PEA if fatty acid binding proteins Participate in a predominant part in its intracellular transport subsequent its u
PPAR‐α is usually a nuclear receptor protein that belongs for the relatives of PPARs and acts as transcription component regulating gene expression (Issemann and Green, 1990).Costa and colleagues [178] have suggested that PEA was in a position to lower mechanical allodynia and thermal hyperalgesia following sciatic nerve constriction in mice, by
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